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KMID : 0377619620030020163
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Korean Jungang Medical Journal
1962 Volume.3 No. 2 p.163 ~ p.172
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Comparative Study on the Effect of Procaine amide and Quinidine on Some Experimentally induced Arrhythmias
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Abstract
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The antiarrhythmic and arrhythmytogenic effects of quinidine and procaine amide were investigated on the artificially produced arrhythmias in the whole rabbit and rat.
Both quinidine and procaine amide could protect the rabbit from developing suba?rial thythms by the coaction of vagal stimulation and sympathomimetic amine: l-norepinephrine, l-eponephrine or isoproterenol. The comparison of the potency of these amines to produce ectopc beats during vagalstimulation by the smallest dose of each amine revealed isoproterenol to be much more potent than the others, as shown in other species.
In the rabbit, quinidine seemed to potentiate the arrhythmytogenic effect of the intravenous aconitine, Whereas procaine amide lessened those of aconitine in some cases.
The bradycardia developed by intravenous serotonin in the rat was almost ablished by the pretreament of procaine amide, but quinidine- pretreatment made the serotonin bradycardia more pronounced and prolonged.
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